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Will My Prescription Show Up on a Drug Test?

It depends on the medicine and on the panel. Pact's 10-panel is a lab urine test, Quest Diagnostics unit code 65190N. Some prescription medicines belong to drug classes on that panel, such as amphetamines, benzodiazepines, barbiturates and several opioids. Others are not on Quest's list for it at all. A prescription does not stop the lab from finding a drug. It gives the medical review officer (MRO) a medical reason to look at before the result is final. This guide shows which classes are on the panel, matches common medicines to them, and explains what to do. It is general information, not medical advice. Talk to the MRO or your own doctor about your medicines.

Updated October 14, 2026 · Checked against the official sources listed at the end

The drug classes on Pact's 10-panel

Quest publishes a sheet of its commonly ordered urine panels. For unit code 65190N it lists these drug groups and the drugs it confirms in each:

Amphetamines: amphetamine and methamphetamine.
Barbiturates: amobarbital, butalbital, pentobarbital, phenobarbital and secobarbital.
Benzodiazepines: alprazolam metabolite and oxazepam.
Cocaine metabolites.
Marijuana metabolites.
Methadone.
Methaqualone.
MDA-analogues: MDA and MDMA.
Opiates: codeine and morphine, plus 6-acetylmorphine.
Semi-synthetic opiates: hydrocodone and hydromorphone.
Oxycodones: oxycodone and oxymorphone.
Phencyclidine (PCP).
Propoxyphene.

Common medicines and where they fall

Check the generic name on your pharmacy label, then compare it with the list above. Here is how some common medicines line up. "On the panel" means the drug or its class is on Quest's sheet. It does not tell you what your own result will be.

Adderall (amphetamine): on the panel. A federal SAMHSA guide for doctors says plainly that Adderall is an amphetamine and will test positive for amphetamine.
Lisdexamfetamine (Vyvanse): on the panel through the amphetamines group. Its FDA label says it is a prodrug of dextroamphetamine, which means the body turns it into dextroamphetamine.
Alprazolam: on the panel. Quest's sheet names alprazolam metabolite under benzodiazepines.
Diazepam, temazepam and chlordiazepoxide: benzodiazepines. SAMHSA says these are broken down to oxazepam, which Quest's sheet lists.
Clonazepam and lorazepam: benzodiazepines, but SAMHSA says they don't form oxazepam. It also says screening tests may miss benzodiazepines that don't break down to the compound the test targets. Neither drug is named on Quest's sheet.
Hydrocodone and hydromorphone: on the panel as semi-synthetic opiates.
Oxycodone and oxymorphone: on the panel as oxycodones.
Codeine and morphine: on the panel as opiates.
Methadone: on the panel.
Butalbital and phenobarbital: on the panel as barbiturates.

Medicines not on Quest's list for this panel

Some common medicines are not named on Quest's sheet for 65190N. Examples include gabapentin, trazodone, zolpidem, methylphenidate, buprenorphine, tramadol and fentanyl. The lab reports the drugs on the panel. It does not run a general search for every medicine you take.

"Not on the list" is not a promise, though. Screening tests work by reacting to chemical shapes. SAMHSA warns that substances other than the target drug can react with a screening test and cause a false-positive screen. It gives phentermine, a weight-loss medicine, as one that commonly causes a false-positive first screen for amphetamines. That is one reason every screen that isn't negative goes on to a second, more specific test, and then to the MRO.

How the lab tests your sample

Quest tests urine in two steps. The first step is a screen, usually an enzyme immunoassay, on one portion of the specimen. It quickly sorts out negative specimens. A specimen that is not negative is then tested again on a different portion with gas or liquid chromatography and mass spectrometry. Quest says those instruments can identify the specific drug and tell it apart from other compounds.

Each step has a cutoff. Below the cutoff, the lab reports negative. SAMHSA notes that workplace cutoffs are set high enough to detect levels that suggest drug misuse, but they don't always detect the levels from a normal dose of a medicine. So a medicine in a listed class may or may not reach the cutoff. Don't count on either outcome. Our guide to 10-panel cutoff levels lists every number for this panel.

What the medical review officer does with a prescription

You don't list your medicines at the collection site. Quest's donor instructions say the collector will not note any prescription drugs on the custody form.

If the lab result on Pact's 10-panel is not negative, it goes to the MRO. The MRO is a licensed physician who contacts the person tested to ask about prescriptions before the result is final. Pact's MRO is DRS. Keep your phone on and answer calls from numbers you don't know while you wait.

Federal DOT rules show how this review works. They don't govern Pact's non-DOT test, but they are the most detailed public description of MRO review. Under 49 CFR 40.137, the MRO must not question whether your doctor should have prescribed the medicine. Under 40.141, the MRO may contact your doctor, and may contact your pharmacy to check that the prescription was filled. If there is a legitimate medical explanation, the MRO verifies the test as negative (40.137(d)). How Pact's MRO words a non-DOT report is something to ask Pact about.

What to have ready, and what not to do

The name of each medicine, as on the label.
Your prescriber's name and phone number.
Your pharmacy's name and phone number, and the fill date if you have it.
A phone that's on, with voicemail set up, in the days after your test.
Don't stop, skip or change a medicine because of a drug test. Ask your prescriber first.
Don't take anyone else's medicine. A prescription only explains a result if it is yours.

Do you have to tell the employer what you take?

The Americans with Disabilities Act says a test to determine the illegal use of drugs is not a medical examination (42 U.S.C. 12114(d)(1)). It also says the ADA doesn't encourage, prohibit or authorize drug testing (12114(d)(2)). On a Pact order, questions about prescriptions come from the MRO, not from the collector. If you have a question about what your employer may ask you, talk to the employer or an attorney. This page isn't legal advice.

Common questions

Will Adderall show up on a 10-panel drug test?

Pact's 10-panel tests for amphetamines, and SAMHSA says Adderall is an amphetamine and will test positive for it. If the lab result isn't negative, the MRO will contact you to ask about your prescription before the result is final.

Does gabapentin show up on Pact's 10-panel?

Gabapentin is not on Quest's published list for unit code 65190N. The lab reports the drugs on the panel. Any screen that isn't negative is confirmed with a second test and reviewed by the MRO.

Should I bring my prescription bottle to the test?

Quest says its collector will not note prescription drugs on the custody form, so the collection site doesn't need it. Keep the details handy for the MRO, who will call you if the lab result isn't negative.

Should I stop taking my medicine before a drug test?

No. Don't stop, skip or change a medicine because of a test. Ask your prescriber. A valid prescription is something the MRO reviews.

Is this medical advice?

No. It is general information about how Pact's test and MRO review work. Talk to the MRO or your doctor about your own medicines.